Phase Separation Drives Heterochromatin Domain Formation
نویسندگان
چکیده
منابع مشابه
Dynamic domain formation in membranes: thickness-modulation-induced phase separation.
A simple model investigates the amplification of fluctuations on membranes constituted of two lipids having different lengths. Van der Waals and electrostatic interactions across the lipid bilayer result in a destabilization favoring thickness variations of the membrane. Close to spontaneous demixing of the two components, the additional gain in free energy due to thickness undulations shifts t...
متن کاملEffect of membrane characteristics on phase separation and domain formation in cholesterol-lipid mixtures.
We examine, using an analytical mean-field model, the distribution of cholesterol in a lipid bilayer. The model accounts for the perturbation of lipid packing induced by the embedded cholesterol, in a manner similar to that of transmembrane proteins. We find that the membrane-induced interactions between embedded cholesterol molecules vary as a function of the cholesterol content. Thus, the eff...
متن کاملWhat Drives a Separation — the Stationary Phase or the Mobile Phase?
influence the driving force. Thermodynamic quantities determined from homologous series retention throughout the entire composition range may lead to a better understanding of the driving force and fundamental retention mechanism that results from the inherent differences in chromatographic solvation between acetonitrile and methanol. Tan and co-workers (11) showed that stationary-phase composi...
متن کاملPhase Separation and Domain Interaction in Pheophytin Containing Monolayers
Surface pressure and fluorescence intensity of pheophytin containing lipid-monolayers are measured simultaneously at the air-water interface. A phase separation into two distinct phases is reported. Phase 1 exists of pheophytin domains whereas phase 2 is a lipid domain containing pheophytin in molar content between 2 % and 15 %, depending on the state of the lipid. The transition of the pheophy...
متن کاملBeyond NMF: Time-Domain Audio Source Separation without Phase Reconstruction
This paper presents a new fundamental technique for source separation of single-channel audio signals. Although nonnegative matrix factorization (NMF) has recently become very popular for music source separation, it deals only with the amplitude or power of the spectrogram of a given mixture signal and completely discards the phase. The component spectrograms are typically estimated using a Wie...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2018
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2017.11.2460